Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells
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چکیده
منابع مشابه
Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract
Some melatonin functions in mammals are exerted through MT₁ and MT₂ receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the...
متن کاملMelatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.
In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In the liver, melatonin suppresses oxidative damage and ameliorates fibrosis. No information exists...
متن کاملHuman Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2
BACKGROUND AND AIM The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans. This study aims to map the expression of melatonin and its two receptors in human GI tract and pancreas using microarray analysis and immunohistochemistry. METHOD Gene expression data from normal intestine and pancreas and ...
متن کاملIdentification and immunolocalization of MT1 and MT2 melatonin receptors in Rasa aragonesa ram spermatozoa
Complete List of Authors: Casao, Adriana; Instituto de Investigación de Ciencias Ambientales de Aragón (IUCA), Facultad de Veterinaria, Universidad de Zaragoza, Grupo Biología y Fisiología de la Reproducción Gallego, Margarita; Universidad de Zaragoza, Patología Animal Abecia, Jose Alfonso; Instituto de Investigación de Ciencias Ambientales de Aragón (IUCA), Facultad de Veterinaria, Universidad...
متن کاملPineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease.
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties. Melatonin and its receptors MT1 and MT2, which belong to the family of G protein-coupled receptors, are impaired in Alzheimer's disease (AD) with severe consequences to neuropatho...
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ژورنال
عنوان ژورنال: Melatonin Research
سال: 2019
ISSN: 2641-0281
DOI: 10.32794/mr11250044